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October 07.2025
2 Minutes Read

Crystalys Therapeutics Aims to Revolutionize Gout Treatment with $205 Million Funding

Crystalys Therapeutics Launches With $205 Million, De-risked Drug Candidate

A Game-Changer for Gout Sufferers

Crystalys Therapeutics has emerged from stealth mode with significant funding to tackle an often debilitating condition that affects millions globally. With over 50 million cases of gout worldwide, including nearly 10 million in the U.S., the company's new drug candidate, dotinurad, could revolutionize treatment for those who fail to respond to traditional therapies.

The Problem with Current Treatments

For decades, gout management has relied heavily on allopurinol, a medication that reduces uric acid production but doesn't address the root problem: the body's difficulty in excreting uric acid through the kidneys. This limitation has left a significant portion of patients – about half who take allopurinol – with uncontrolled gout, which can lead to painful episodes and permanent joint damage due to the formation of tophi (deposits of uric acid crystals).

Dotinurad: A Promising Alternative

Dotinurad, a URAT1 inhibitor, addresses this issue by blocking a protein in the kidney that causes uric acid reabsorption. As a result, patients can excrete uric acid more efficiently, potentially resolving chronic symptoms associated with the disease. CEO James Mackay emphasizes the need for alternatives, stating, “The second-line treatment space is empty,” revealing an unmet medical need.

Funding and Development Pathway

The company recently launched a $205 million funding round, co-led by Novo Holdings and other prominent investors. This influx of capital will enable Crystalys to accelerate Phase 3 clinical trials for dotinurad. One trial intends to prevent gout flares, while another aims to resolve existing tophi. Notably, the drug is already approved in several Asian countries and has a strong safety record, making its accelerated entry into U.S. trials particularly promising.

Market Demand and Future Implications

Mackay's history with previous biotech ventures provides a background that bolsters confidence in the success of dotinurad. Given the market dynamics and limitations of existing treatments like Amgen’s Krystexxa, which, despite its effectiveness, is limited by its high cost and administration frequency, market analysts foresee a strong potential for new entrants like Crystalys. With the focus shifting to patient-centric solutions, the time is ripe for innovations in gout treatment.

Broader Impact on Health and Wellness

The rise of companies like Crystalys Therapeutics not only highlights advancements in medical therapy but also underlines the critical need for ongoing research in chronic conditions like gout. An effective treatment can significantly improve quality of life for millions, thereby reducing healthcare costs linked to untreated chronic illnesses and prompting further investment in biotech solutions.

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10.03.2025

L.A. Healthcare Workers Rally Against Cuts: What It Means for Communities

Update A Rally for Change: L.A. Healthcare Workers Unite On a crisp October afternoon, the Los Angeles Convention Center buzzed with the energy of over 1,000 passionate healthcare workers and locals, rallying against proposed cuts to Medicare and Medicaid. The event, organized by St. John’s Community Health, isn’t just a response to federal budget proposals; it symbolizes a growing frustration among everyday citizens who fear losing their access to affordable healthcare. A Community in Crisis At the heart of the rally, workers voiced the pressing concerns stemming from President Trump's "Big Beautiful Bill," which threatens to slice nearly a trillion dollars from essential health programs. Romond Phillips, a dedicated mobile clinic driver, encapsulated the sentiment, stating, "Healthcare right now in America is bad. I’m out on the front lines, so I see the need for it." His words resonated with many who shared personal stories, like David Rolas, a South L.A. resident who needs insulin to manage his diabetes. “I want to make sure I'm around for my kids,” Rolas said. “But I will be affected by these changes.” Political Tensions Heightened by Shutdown This rally comes at a critical juncture, as a government shutdown looms over the healthcare discussion. The Democratic Senate block against a Republican funding bill highlighted the stakes, with a demand for extending premium tax credits crucial for affordable healthcare plans. Without these extensions, millions risk facing heightened insurance premiums or losing coverage altogether. Why This Matters to You and Your Family The implications of these federal healthcare cuts are felt deeply, especially in areas like Bakersfield, CA, where access to healthcare services can heavily influence the wellbeing of families. With a significant number of residents relying on programs like Medi-Cal, a loss of support could spell disaster, pushing many into financial distress as they struggle to afford necessary medical treatments. The Fight for Local Initiatives In response to these looming cuts, St. John’s announced plans to introduce a county ballot measure aimed at securing hundreds of millions for local healthcare initiatives. The measure, dubbed the Los Angeles County Emergency and Essential Healthcare Restoration Measure, seeks voter approval to stabilize funding for community healthcare services. Jim Mangia, president of St. John’s, stated this initiative is essential to "build a national example" for how communities can rally for their health needs. The funds would notably counteract losses resulting from Trump's proposed cuts, aiming to protect the most vulnerable residents. Solidarity from Local Leaders County Supervisor Holly Mitchell and Congresswoman Sydney Kamlager-Dove were among the leaders who expressed their commitment to preventing a return to the pre-Obamacare landscape. “I don’t know about you, but I’m not going back,” Mitchell declared, reflecting the sentiments of many who stood in front of the Convention Center. The local impact of these policies means more than healthcare; it ties into the very fabric of our social safety net. Looking Ahead: A Call to Action The solidarity displayed at the rally reignites hope for many communities who fear losing more than just their healthcare. As advocates work to inform and engage the public on this crucial issue, it’s vital for individuals to become involved in local discussions and initiatives. Whether through attending community forums, sharing experiences, or simply staying informed, each action contributes to building a healthier future for everyone. Join the Effort If you want to make a difference in your community's healthcare landscape, consider participating in local health initiatives or attending upcoming meetings to discuss the Los Angeles County ballot measure. Your voice matters, and together we can advocate for better access to affordable healthcare for all. Remember, every effort counts—join us in ensuring that healthcare remains a right and not a privilege.

10.03.2025

Join the Conversation: Explore Key Insights From Q3 2025 Stakeholder Newsletter

Update Discover the Latest Insights in the Q3 2025 Stakeholder Newsletter The Anti-Racism, Inclusion, Solidarity, and Empowerment (ARISE) Division of the Los Angeles County Department of Mental Health has unveiled its much-anticipated fourth edition of the Quarterly Stakeholder Newsletter. This publication is more than just a newsletter; it’s a dedicated platform where voices of mental health consumers, advocates, and their allies come together to share stories and experiences that matter to them. Connecting Communities Through Shared Experiences The significance of this newsletter extends beyond its pages. It serves as a bridge that unites individuals facing similar challenges and triumphs in the realm of mental health. As communities grapple with ongoing crises—like the demands of post-pandemic recovery and escalating mental health issues—having a platform that amplifies lived experiences is more crucial than ever. These contributions not only validate personal stories but also foster solidarity and understanding within the community. What to Expect in This Issue The latest issue is rich with content that reflects the diverse experiences and insights of its contributors. Stakeholders can expect stories centered on resilience, coping strategies, and strategies for activism, all tailored to encourage reader engagement and facilitate dialogues on mental health. It reassures us that we are not alone in our journeys. Emphasizing the Importance of Diverse Voices At the forefront of this newsletter is a commitment to inclusivity. By featuring contributions from individuals with varying backgrounds and experiences, the ARISE Division actively engages stakeholders across the spectrum of mental health. This approach enhances the newsletter's value, turning it into a collaborative effort to support mental wellness. Breaking Barriers to Participation Dr. Lisa H. Wong, the director of LACDMH, emphasizes the newsletter's role in breaking barriers to participation in mental health discussions. “We want to ensure that all voices are heard in this crucial conversation,” she states. This is particularly relevant for communities in and around Bakersfield, where access to mental health resources has historically been inconsistent. By providing centralized information and fostering connections, the newsletter plays a pivotal role in advocacy and outreach. Why Participation Matters Readers are encouraged not only to consume the content but also to become contributors. Sharing personal journeys or insights can empower others who may feel isolated in their mental health experiences. As the ARISE Division highlights in this edition, your story can inspire hope and stimulate change within the mental health landscape. The Impact of Staying Informed Staying engaged with newsletters like this one reinforces the importance of being informed about ongoing developments in mental health services. It encourages individuals to connect with local resources and support systems designed to enhance mental well-being. It also invites participation in future initiatives, fostering a sense of community in addressing mental health challenges. Your Role in Shaping Future Editions As the ARISE Division looks ahead to future issues, community members are reminded of their vital role in shaping the newsletter's content. Your experiences and insights are invaluable, and contributions can drive discussions that lead to actionable change. Remember, the newsletter is a platform for you, and your voice matters. Join the Conversation! As we wrap up this overview of the Q3 2025 Stakeholder Newsletter, we invite you to dive deep into its pages. Engage with the stories, share your thoughts, and submit your own experiences to help foster a sense of community and support for mental health. The next edition awaits your contributions, and together, we can create a narrative that resonates with many.

09.30.2025

After Months of Closure, Cupertino Whole Foods Reopens: What to Expect

Update Cupertino Whole Foods Finally Reopens After Extensive Closure After a challenging five months of closure due to a severe rodent infestation, the Whole Foods Market on Stevens Creek Boulevard in Cupertino has reopened its doors to eager customers. The store's temporary closure was initiated after Santa Clara County health inspectors discovered alarming levels of vermin, including rodent droppings in food-preparation areas and live cockroaches in the bakery, leading to an urgent sanitation process. The Impact of the Closure on the Community During the closure, many loyal customers resorted to shopping at the nearby Whole Foods in Sunnyvale. The news of the reopening has brought relief and excitement among residents, eager to return to their favorite grocery store. "It was disappointing to see all the news about the rodent infestation, but hopefully, it won't repeat again," said customer Prateek Kakirwar, expressing a sentiment shared by many as they flock back to the store. Tackling Rodent Infestations: County Health Insights Dr. Marilyn Underwood, Environment Health director for Santa Clara County, noted that this year's pest-related closures have been more frequent than in previous years, drawing attention to a growing issue. It was emphasized that California's new restrictions on anticoagulant rodenticides possibly contributed to the store's lengthy closure. These control methods, denied to the store in their waiver request, could have returned the market to operation sooner. Improvements Made for Customer Safety The reopening comes with assurances of enhancements throughout the store. A comprehensive renovation was undertaken, including sanitization measures, structural repairs, and improvements to pest management tactics. Whole Foods expressed their commitment to customer safety with statements like, "We have made extensive updates to the store ensuring an improved shopping experience for our customers." These efforts included adding door sweeps at entry points and carrying out thorough cleaning across all departments. The Broader Implications for Food Safety Regulations This incident shines a light on food safety regulations and the responsibilities of retailers to maintain health standards. As health officials continue to monitor the situation with routine inspections, it sparks conversation about the effectiveness of current pest control measures in combating vermin in grocery environments. With areas affected by similar issues, local communities may gain insights into the significance of stringent health codes and proactive measures by retailers. What This Means for Local Shoppers While the reopening is a positive development, shoppers will likely remain vigilant and curious about the store's health safety moving forward. This situation highlights not only the importance of food safety but also how businesses approach cleanliness and consumer trust. With the Whole Foods in Cupertino back in operation, it’s a confrontation between community concern and the necessity for quality shopping experiences. As the reopening is celebrated, shoppers are reminded to stay informed about food safety practices in their local markets, and how they can contribute to maintaining high standards of hygiene. For residents around Cupertino, the Whole Foods revival is not just a return to convenience but a fresh perspective on the importance of community health and safety.

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